Publisher's Synopsis
Written by some of the world's foremost authorities on Alzheimer disease from all relevant basic science fields and clinical specialties, this volume is aims to provide a definitive reference on Alzheimer disease (AD). The book provides an in-depth review of current concepts on every aspect of AD - from its molecular and cellular bases to its inheritance patterns, signs and symptoms, associated anatomic and biochemical pathologies, diagnosis, and therapy.;Coverage includes diagnostic criteria, neuropsychology, clinical genetics, epidemiology, and MRI, CT, and PET imaging. Noted investigators discuss current theories on the cell types vulnerable to damage in AD; the underlying alterations in neurotransmitters, neuropeptides, neurotropic factors, receptors, and signal transduction mechanisms; the protein constituents of the neuritic plaques and neurofibrillary tangles; the molecular genetics of AD; and the role of trace elements in its pathogenesis. The book concludes with reviews of clinical trials and experimental therapeutics.
