Publisher's Synopsis
Cellular and Molecular Mechanisms of Hormonal Carcinogenesis
ENVIRONMENTAL INFLUENCES
Edited by James Huff, Ph.D., Jeff Boyd, Ph.D., and J. Carl Barrett, Ph.D.
The influence of hormonal perturbations on carcinogenesis is attracting increased research attention today—a trend encouraged by the mounting number of both natural and synthetic hormone–mimetic agents found in certain drugs, industrial products or wastes, and elsewhere in the contemporary environment.
Cellular and Molecular Mechanisms of Hormonal Carcinogenesis: Environmental Influences offers an authoritative, up–to–date overview of the role of environmental factors in the development of hormonally modulated cancers—as well as a comprehensive account of the latest research into the basic mechanisms of hormonal carcinogenesis in both human and animal models. The text opens with a review of the central issues relevant to environmental factors and hormonal carcinogenesis, including time trends, dietary effects, and chemically induced hormonal cancers. Subsequent sections examine molecular mechanisms and experimental and human mechanistic studies. Finally, the book closes with essays offering unique perspectives on this area, plus a discussion of the potential future of the field.
Some of the specific topics covered in the text include:
- Dietary influences on tumors of hormonal tissues
- Modulating effects of hormones on carcinogenesis
- Transplacental hormonal carcinogenesis (diethylstilbestrol as an example)
- Estrogen as a carcinogen: genetics and molecular biology of human endometrial carcinoma
- Mechanisms of chemically induced follicular cell carcinogenesis of the thyroid gland
- Environmental causes of breast cancer: future research directions
Featuring contributions from leading experimental and epidemiological researchers, Cellular and Molecular Mechanisms of Hormonal Carcinogenesis: Environmental Influences effectively summarizes the current status of this increasingly important area, and offers valuable data to guide ongoing investigations in the field. Biomedical and clinical researchers in oncology or endocrinology and cell/development biologists—particularly those interested in growth regulation or environmental toxicology—will find this work a stimulating and useful resource.
