Publisher's Synopsis
Published by Sinauer Associates, an imprint of Oxford University Press. The only book that, in one place: - details the three main epigenetic sources of phenotype: symbionts, altered chromatin structure, and plasticity. - discusses the various ways that development can be disrupted: teratogens, endocrine disruptors, global climate change, and mismatches between diet and environment. - documents the evidence for an extended evolutionary synthesis involving the modern synthesis, evo-devo, and eco-evo-devo. The revolution in molecular technologies has created a revolution in our perception of the living world. It is life, but not as we knew it. * Symbiosis, once thought the exception to the rules of life, is now recognized as a signature of life, including its development and evolution. We function, develop, and possibly evolve as consortia. * Developmental plasticity has transformed our ways of relating the genome to both the organism and its environment, showing that the environment can instruct, as well as select, phenotypes. * Environmentally induced modifications of the genome (epialleles) can be created by ecological agents and inherited for many generations, showing the ability of environmental agents to generate selectable variation. * Disease susceptibilities--especially to diseases such as cancer, diabetes, asthma, autism, and obesity--may be inherited through epialleles caused by environmental agents, by mismatches in developmental plasticity, or by particular combinations of symbionts. * Global climate change and endocrine disruptors are affecting how organisms develop and how they behave. The science studying this new world, uncovering the relationships between genes, developing organisms, and their environments, is called ecological developmental biology. This book presents the data for ecological developmental biology, integrating it into new accounts of medicine, evolution, and embryology. The new evolutionary science created by this approach to nature is called ecological evolutionary developmental biology (eco-evo-devo). The book documents the evidence for a new, extended, evolutionary synthesis, a synthesis that: confounds the creationist belief that evolution can't be described above the species-level; integrates aging and "Western" diseases such as diabetes, atherosclerosis, cancer, and obesity into an evolutionary context; and sees interspecies interactions both within the organism and between organisms as being critical for evolution, development, and fitness.
