Growth Hormone Secretagogues in Clinical Practice

Growth Hormone Secretagogues in Clinical Practice

Hardback (28 Apr 1998)

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Publisher's Synopsis

Recognizing the urgent need for an up-to-date review of new and innovative research on growth hormone (GH) secretagogues, this exclusive work furnishes the state of the art on the mechanisms of action, design, synthesis, evaluation, and clinical applications of GH secretagogues, including orally active and xenobiotic GH-releasing compounds.
Beginning with a thorough historical perspective on the discovery and evolution of GH-releasing peptides (GHRPs) as therapeutic agents, Growth Hormone Secretagogues in Clinical Practice

  • analyzes structural requirements for GH secretagogue efficacy
  • demonstrates the use of mathematical models to predict differential values of individual stimuli for GH secretion from the pituitary
  • reports on the development of a simple screening system based on polyclonal antibodies
  • discusses laboratory synthesis of agonistic analogs intended for human and veterinary use
  • proposes applications in managing conditions such as Turner's syndrome, acromegaly, diabetic retinopathy, glomerulosclerosis, tumors, and cancer
  • provides physiological evidence for the effects of GHRP on behavior with a series of trials involving voluntary and forced exercise
  • describes a new diagnostic test for evaluating pituitary function in slowly growing children and aging adults
  • explores the interactions of GH secretagogues with other hormones and endogenous substances from sex steroids to interferons
  • and much more!
  • Book information

    ISBN: 9780824798321
    Publisher: CRC Press
    Imprint: CRC Press
    Pub date:
    DEWEY: 615.363
    DEWEY edition: 21
    Language: English
    Number of pages: 436
    Weight: 754g
    Height: 229mm
    Width: 152mm
    Spine width: 30mm